SUPPLEMENTARY TEXT Positive Regulatory Dynamics by DsrA noncoding RNA
نویسندگان
چکیده
1 Department of Condensed Matter Physics, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain, and Instituto ’Nicolás Cabrera’, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain 2 Laboratoire Léon Brillouin, Commissariat lEnergie Atomique, CNRS-UMR 12, CEA-Saclay, Gif-surYvette Cedex F-91191 3 Laboratoire Jean Perrin, FRE 3132 CNRS-Paris 6 Paris F-75006 4 Universit Paris Diderot Paris 7 Paris F-75013 5 Unit de Biologie Fonctionnelle et Adaptative (BFA), CNRS EAC 4413, Universit Paris Diderot-Paris 7, Paris F-75013
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Positive regulatory dynamics by a small noncoding RNA: speeding up responses under temperature stress.
Recent discoveries of noncoding regulatory RNAs have led to further understanding of the elements controlling genetic expression. In E. coli, most of those ncRNAs for which functional knowledge is available were shown to be dependent on the Hfq RNA chaperone and to act as inhibitors of translation by base pairing with their mRNA target. Nevertheless, there are also some examples where the sRNA ...
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DsrA is an Escherichia coli small noncoding RNA that acts by base pairing to some mRNAs in order to control their translation and turnover. It was recently shown that DsrA is able to self-associate in a way similar to DNA and to build nanostructures. Although functional consequence of this RNA self-assembly in vivo is not yet understood, the formation of such an assemblage more than likely infl...
متن کاملIdentification of the Hfq-binding site on DsrA RNA: Hfq binds without altering DsrA secondary structure.
DsrA RNA regulates the translation of two global regulatory proteins in Escherichia coli. DsrA activates the translation of RpoS while repressing the translation of H-NS. The RNA-binding protein Hfq is necessary for DsrA to function in vivo. Although Hfq binds to DsrA in vitro, the role of Hfq in DsrA-mediated regulation is not known. One hypothesis was that Hfq acts as an RNA chaperone by unfo...
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Food and other environmental factors affect gene expression and behaviour of animals. Differences in bacterial food affect the behaviour and longevity of Caenorhabditis elegans. However, no research has been carried out to investigate whether bacteria could utilize endogenous RNAs to affect C. elegans physiology. Here we show that two Escherichia coli endogenous noncoding RNAs, OxyS and DsrA, i...
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